KUPIR ASOSIDA YUMSHOQ DORI SHAKLINI VITILIGO KASALLIGIDA QO‘LLASH IMKONIYATLARINI O‘RGANISH
Keywords:
kupir, vitiligo, yumshoq dori shakllari, mis ionlari, vitamin B6 (piridoksin), melanositlar, immunomodulyator ta’sir.Abstract
Mazkur maqolada vitiligo kasalligini davolashda kupir asosida yumshoq dori shakllarini qo‘llash imkoniyatlari o‘rganilgan. Vitiligo – pigment yetishmovchiligi bilan tavsiflanadigan surunkali dermatologik kasallik bo‘lib, uning zamonaviy terapiya usullari yetarli samaradorlikni ko‘rsatmaydi. Shuning uchun innovatsion dorivor vositalarni izlash va ishlab chiqish muhim ahamiyat kasb etadi. Tadqiqot davomida kupirning farmakologik xususiyatlari, uning teriga ta’siri va immunomodulyator, antioksidant hamda yallig‘lanishga qarshi xususiyatlari o‘rganildi. Kupir asosida tayyorlangan gel, malham va krem kabi yumshoq dori shakllarining teriga singish darajasi, terapevtik samaradorligi va xavfsizligi eksperimental va klinik tadqiqotlar asosida baholandi. Olingan natijalar kupir asosidagi preparatlarning vitiligo terapiyasida istiqbolli ekanligini ko‘rsatdi. Ushbu dori shakllari melanositlarning faoliyatini tiklashga yordam beradi, teridagi oksidativ stressni kamaytiradi hamda immun tizimining muvozanatini ta’minlaydi. Shuningdek, maqolada kupir asosidagi yumshoq dori vositalarini vitiligo bilan kasallangan bemorlarda klinik jihatdan qo‘llash istiqbollari va keyingi tadqiqotlar uchun tavsiyalar keltirilgan. Tadqiqot natijalari vitiligo kasalligiga chalingan bemorlar uchun yangi va samarali davolash usullarini ishlab chiqishda muhim ilmiy asos bo‘lishi mumkin.
References
1. Taieb A., Picardo M. "Vitiligo: New developments in epidemiology, pathogenesis, and treatment". Journal of Investigative Dermatology, 2019.
2. GF XI, chiqgan 1-son, 16-bet
3. Copper biochemistry and molecular biology, https://pubmed.ncbi.nlm.nih.gov/8615367/
4. Рахимова Д. Ф. Биоактивность витамина в 6 и его производных (краткий обзор зарубежных публикаций) //Вестник Казанского технологического университета. – 2012. – Т. 15. – №. 16. – С. 181-183.
5. Rodrigues M., Ezzedine K., Hamzavi I. "Current and emerging treatments for vitiligo". Journal of the American Academy of Dermatology, 2021.
6. Ortonne J.P. "Vitiligo and other disorders of hypopigmentation". Springer, 2018.
7. Bose S.K., Jansen T. "Topical and systemic therapies for vitiligo: An updated review". Dermatologic Therapy, 2020.
8. Krüger C., Schallreuter K. U. "A Review of the Worldwide Prevalence of Vitiligo in Children and Adults." International Journal of Dermatology, vol. 51, no. 10, 2012, pp. 1206–1212.
9. Le Poole C., Luiten R. "Autoimmune Aspects of Vitiligo." Journal of Investigative Dermatology, vol. 118, no. 3, 2002, pp. 371–378.
10. Schallreuter K. U. et al. "Vitiligo—An Autoimmune Disease?" Experimental Dermatology, vol. 21, no. 10, 2012, pp. 731–737.
11. Njoo M. D., Westerhof W. "Vitiligo: Pathogenesis and Treatment." American Journal of Clinical Dermatology, vol. 2, no. 3, 2001, pp. 167–181.
12. Ezzedine K. et al. "Vitiligo: What’s New in Diagnosis and Management?" Journal of the European Academy of Dermatology and Venereology, vol. 29, no. 3, 2015, pp. 1–8.
