FOLAT SIKLI GENLARI ALLEL POLIMORFIZMLARI VA ULARNING GEMOSTAZ TIZIMIGA TA’SIRI
Keywords:
folat sikli, allel polimorfizmlar, MTHFR C677T, gomosistein, gemostaz, tromboz xavfi, metafolin, DNK metilatsiyasi.Abstract
Folat sikli genlaridagi allel polimorfizmlar, xususan MTHFR (C677T va A1298C), MTR (A2756G) va MTRR (A66G) genlaridagi o‘zgarishlar gemostaz tizimining faoliyatiga sezilarli ta’sir ko‘rsatadi. Ushbu polimorfizmlar gomosistein darajasining oshishiga olib kelib, trombogenez xavfini kuchaytiradi. Masalan, MTHFR C677T polimorfizmining T allelini tashuvchi shaxslarda ferment faolligining pasayishi natijasida gomosistein darajasi oshadi. Bu esa yurak-qon tomir kasalliklari va tromboembolik holatlar xavfini oshiradi [1].
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