TISH KARIESI PATOGENEZIDA STREPTOCOCCUS MUTANSNING ROLI
Keywords:
Tish kariyesi va uning patogenezi, klinik kuzatuvlar hamda tahlillar, mutans turiga mansub streptokokklar, Streptococcus mutans bakteriyasi, karies hosil qiluvchi biomahsulot, kariyesga sabab bo‘luvchi mikroflora, og‘iz bo‘shlig‘ining immun reaksiyasiAbstract
Tish kariesi butun dunyoda keng tarqalgan muhim sog‘liq muammosidir. Ushbu kasallik og‘iz bo‘shlig‘idagi mikroorganizmlar va odam organizmi o‘rtasidagi noto‘g‘ri o‘zaro ta’sirlar natijasida yuzaga keladi. Bu o‘zaro ta’sirlar tish sirtida kariyes keltirib chiqaruvchi biomahsulotlar hosil bo‘lishini rag‘batlantiradi. Ushbu moddalarning yuqori va uzoq muddatli kislota hosil qilish qobiliyati tish to‘qimalarining demineralizatsiyasiga olib keladi. Bu jarayonlar tashqi muhit omillari, ayniqsa parhez (ratsion) tarkibidagi uglevodlar miqdori bilan chambarchas bog‘liq. Mikroorganizmlar tish kariesining rivojlanishida markaziy rol o‘ynashi allaqachon isbotlangan bo‘lsa-da, hozirgi vaqtda kariyesga sabab bo‘luvchi moddalarning shakllanishiga qarshi samarali aralashuv usullari cheklangan.Ushbu tahliliy maqolada biz mutans streptokokklar (MS) guruhining kariyesga moyil mikrobiota shakllanishidagi rolini tasdiqlovchi klinik tadqiqotlarga e’tibor qaratdik. Jarayonda Streptococcus mutans — eng mashhur MS turi — ning genetik va fenotipik xilma-xilligi haqidagi hozirgi ilmiy ma’lumotlar asosida uning funksiyalari tahlil qilinadi. Shuningdek, mezbonning immun javoblarining S.mutans kolonizatsiyasi va patogeneziga ta’siri ham muhokama qilinadi. Ushbu ma’lumotlar S. mutans ga qarshi terapiyalarni sinovdan o‘tkazish bo‘yicha qo‘shimcha tadqiqotlarni rag‘batlantiradi.
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