BIOCHEMICAL MARKERS OF BONE METABOLISM IN ALLOXAN OSTEOPATHY AND WAYS OF THEIR CORRECTION
Keywords:
Bone metabolism, P1NP, CTX-I, calcium, glycosaminoglycans , diabetic osteopathyAbstract
Changes in biochemical markers of bone metabolism ( Ca , P, alkaline phosphatase, P1NP, CTX-I) and the effectiveness of their correction using calcium, sulfated glycosaminoglycans (GAGs), and their combination were studied in an experiment on rats with alloxan -induced diabetes mellitus. It was revealed that the development of diabetic osteopathy is accompanied by a significant decrease in serum calcium and phosphorus concentrations, a decrease in the level of the bone formation marker P1NP, and an increase in the resorption marker CTX-I. The use of calcium and GAGs led to a partial restoration of mineral metabolism, and combination therapy provided the most pronounced normalizing effect. The obtained data confirm the role of osteoimmune and endocrine mechanisms in the development of diabetic osteopathy and substantiate the feasibility of comprehensive correction of bone metabolism disorders.
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