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CHRONIC PAIN

Authors

  • Asatullayev Rustam Baxtiyarovich

    Trainee assistant at Samarkand State Medical University
    Author
  • Axmedova Rayxona Umidbek qizi

    Student
    Author

Keywords:

chronic pain,pain management,pharmacological interventions,non-pharmacological therapies,central nervous system, physical rehabilitation, psychosocial impact,multimodal approaches,neuroinflammation

Abstract

Chronic pain is a complex,multifaceted condition that affects millions of individuals worldwide,often disrupting daily functioning and reducing quality of life.Unlike acute pain,which serves as a warning signal of injury,chronic pain persists for months or even years,frequently without an identifiable cause.The pathophysiology of chronic pain involves complex interactions between the peripheral and central nervous systems,neuroplasticity,and psychosocial factors.This review examines the current understanding of chronic pain mechanisms,it’s impact on physical and mental health,andexplores contemporary treatment approachers,ranging from pharmacological interventions to non-pharmacological therapies,including cognitive-behavioral therapy and physical rehabilitation.Despite advancements in pain management,many individuals continue to experience insufficient relief, highlighting the need for personalized, multimodal approaches.Understanding the biopsychosocial model of chronic pain  and integrating it into clinical practice remains crucial for improving patient outcomes and enhancing quality of life

References

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https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03076-2

2.Journal of Chemical Health Risks (JCHR).(2024).Pathophysiology of chronic pain:Central sensitization,neuroinflammation,and maladaptive neural plasticity.Journal of chemical Health Risks,14(3),4235-4250/

https://www.jchr.org/index.php/JCHR/article/view/7159

3.PubMed (U.S.National Library of Medicine).(2023).Psychological and cognitive-behavioral interventions for chronic pain:Effects on inflammation and coping mechanisms.Journal of Pain Research,16,38556371.

https://pubmed.ncbi.nlm.nih.gov/385567371/

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Research,Society and Development,13(6),Article 46707

https://www.rsdjournal.org/rsd/article/view/46707

5.Review of Contemporary Philosophy.(2024).The biopsychosocial model and holistic approaches to pain management.Review of Contemporary Philosophy,23(1),286-604.

https://reviewofconphil.com/index.php/journal/article/view/299

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Published

2025-11-10