ANTIBIOTIKLARNING MIKROORGANIZLARGA TA'SIR MEXANIZMI VA MIKROORGANIZMLARNING ANTIBIOTIKLARGA CHIDAMLILIGI
Keywords:
Antibiotiklar, mikroorganizmlar, ta’sir mexanizmi, chidamlilik, rezistentlik, bakterial o‘sish, betalaktamlar, makrolidlar, mutatsiya, genetik o‘zgarishlar, plazmidlar, fermentlar, antibiotikga sezuvchanlik, antibakterial terapiya, mikrobial rezistentlik.Abstract
Ushbu maqola antibiotiklarning mikroorganizmlarga ta'sir qilish mexanizmlarini va ularga javoban mikroorganizmlarda yuzaga keladigan chidamlilik (rezistentlik) hodisasini chuqur o'rganadi. Unda antibiotiklar hujayra devori sintezini ingibitsiya qilish, oqsil biosintezini buzish, nuklein kislotalar metabolizmini o'zgartirish kabi asosiy ta'sir yo'nalishlari tahlil qilinadi. Shuningdek, bakteriyalarning dori vositalariga chidamlilikni rivojlantirish yo'llari: antibiotikni inaktivatsiya qilish (fermentlar orqali), preparat ta'sir qiladigan nishonni o'zgartirish va antibiotikning hujayraga kirishini kamaytirish (efflyuks mexanizmi) mexanizmlari yoritilgan. Maqola zamonaviy tibbiyot va farmakologiya uchun global muammo bo'lgan antibiotik rezistentligining rivojlanishiga qarshi kurash strategiyalariga e'tibor qaratadi.
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