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BLOOD TRANSFUSION

Authors

  • Asatullayev Rustamjon Baxtiyarovich

    Trainee assistant at Samarkand State Medical University
    Author
  • Erkaboyeva Gulruh

    Student
    Author

Keywords:

Blood transfusion, anemia, red blood cells, plasma, crossmatching, blood safety, donor screening, hematology, transfusion medicine

Abstract

Blood transfusion is a life-saving medical procedure in which donated blood or blood components are transferred into a patient’s circulation to replace lost elements of the blood. It plays a vital role in modern medicine by treating anemia, trauma, surgical bleeding, and various hematological disorders. The development of safe transfusion practices has evolved significantly since the discovery of blood groups by Karl Landsteiner in 1901. Today, blood transfusion safety is ensured through donor screening, crossmatching, component separation, and rigorous infection control standards. However, challenges such as transfusion-transmitted infections, immune reactions, and supply shortages persist in both developed and developing countries. This paper aims to analyze the principles, clinical applications, results, and challenges of blood transfusion practices, based on evidence from WHO, CDC, and peer-reviewed medical studies

References

1. Carson, J. L., Stanworth, S. J., Guyatt, G., & Hébert, P. C. (2016). Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database of Systematic Reviews, (10), CD002042.

2. Roback, J. D., Combs, M. R., Grossman, B. J., & Hillyer, C. D. (2011). AABB Technical Manual (17th ed.). Bethesda, MD: AABB Press.

3. Shander, A., Hofmann, A., Ozawa, S., Theusinger, O. M., Gombotz, H., & Spahn, D. R. (2010). Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion, 50(4), 753–765.

4. Murphy, M. F., & Goodnough, L. T. (2015). Modern blood transfusion: risks and alternatives. The Lancet, 385(9980), 1999–2006.

5. World Health Organization (WHO). (2010). Blood safety and availability. Retrieved from https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability

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Published

2025-11-28