REVMATOID ARTRIT VA OSTEOPOROZ: PATOGENETIK BOG‘LIQLIK
Keywords:
revmatoid artrit, osteoporoz, yallig‘lanish, sitokinlar, suyak metabolizmi, osteoimmunologiyaAbstract
Revmatoid artrit surunkali autoimmun yallig‘lanish kasalligi bo‘lib, bo‘g‘imlarning destruksiyasi va turli tizimli asoratlar bilan kechadi. Osteoporoz revmatoid artritning eng ko‘p uchraydigan va klinik jihatdan ahamiyatli asoratlaridan biri hisoblanadi. Revmatoid artrit bilan og‘rigan bemorlarda suyak mineral zichligining pasayishi, suyak rezorbsiyasining kuchayishi va sinish xavfining ortishi kuzatiladi. Mazkur maqolada revmatoid artrit va osteoporoz o‘rtasidagi patogenetik bog‘liqlik yallig‘lanish sitokinlari, immunologik mexanizmlar, gormonal omillar va glyukokortikoid terapiyasining ta’siri nuqtai nazaridan tahlil qilinadi. Ushbu patogenetik mexanizmlarni tushunish osteoporozning erta tashxisi va samarali profilaktikasini ta’minlashda muhim ahamiyat kasb etadi.
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