THE PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN OBESITY AND TYPE 2 DIABETES MELLITUS
Keywords:
Obesity, Type 2 Diabetes Mellitus, Insulin Resistance, Adipokines, Lipotoxicity, Visceral FatAbstract
Obesity is the primary etiological factor in the development of Type 2 Diabetes Mellitus (T2DM). This relationship is mediated through insulin resistance, chronic low-grade inflammation, and deleterious changes in adipokine secretion. Understanding this nexus is critical for clinical intervention and long-term management of metabolic syndrome.
References
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