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CHRONIC PAIN

Authors

  • Amonturdiyev Og`abek Alisherovich

    Faculty of General medicine, Samarkand State Medical University Group 153
    Author
  • Asatullayev Rustamjon Bakhtiyarovich

    Scientific supervisor
    Author

Keywords:

chronic pain, pain management, central sensitization, neuropathic pain, inflammation, quality of life, cognitive-behavioral therapy, multidisciplinary treatment, mental health, long-term illness

Abstract

Chronic pain is a persistent and complex medical condition that lasts for more than three months and often continues beyond normal tissue healing. It arises from a variety of causes, including musculoskeletal disorders, nerve damage, and systemic diseases, and may involve both peripheral and central sensitization mechanisms. Unlike acute pain, chronic pain is not solely a symptom but a distinct pathological state that significantly affects physical functioning, psychological well-being, and overall quality of life. Patients frequently experience reduced mobility, sleep disturbances, anxiety, and depression, creating a multidimensional burden. Effective management requires a comprehensive, interdisciplinary approach combining pharmacological treatments, physical rehabilitation, psychological support, and lifestyle modifications. Despite advances in understanding and treatment, chronic pain remains a major global health issue, necessitating continued research and patient-centered care strategies

References

1. Treede R.-D., Rief W., Barke A., Aziz Q., Bennett M. I., Benoliel R., et al. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). – Pain, 2019. – Vol. 160(1). – p. 19–27. (Total pages: 9, cited: p. 20)

2. Turk D. C., Wilson H. D., Cahana A. Treatment of chronic non-cancer pain. – The Lancet, 2011. – Vol. 377(9784). – p. 2226–2235. (Total pages: 10, cited: p. 2228)

3. Woolf C. J. Central sensitization: implications for the diagnosis and treatment of pain. – Pain, 2011. – Vol. 152(3 Suppl). – p. S2–S15. (Total pages: 14, cited: p. S5)

4. Gatchel R. J., Peng Y. B., Peters M. L., Fuchs P. N., Turk D. C. The biopsychosocial approach to chronic pain: scientific advances and future directions. – Psychological Bulletin, 2007. – Vol. 133(4). – p. 581–624. (Total pages: 44, cited: p. 585)

5. Mills S. E. E., Nicolson K. P., Smith B. H. Chronic pain: a review of its epidemiology and associated factors. – British Journal of Anaesthesia, 2019. – Vol. 123(2). – p. e273–e283. (Total pages: 11, cited: p. e275)

6. Goldberg D. S., McGee S. J. Pain as a global public health priority. – BMC Public Health, 2011. – Vol. 11(1). – p. 770. (Total pages: 5, cited: p. 771)

7. Eccleston C., Crombez G. Worry and chronic pain: a misdirected problem solving model. – Pain, 2007. – Vol. 132(3). – p. 233–236. (Total pages: 4, cited: p. 234)

8. National Institute for Health and Care Excellence (NICE). Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management. – London, 2021. (Total pages: 36, cited: p. 12)

9. Apkarian A. V., Bushnell M. C., Treede R.-D., Zubieta J.-K. Human brain mechanisms of pain perception and regulation in health and disease. – European Journal of Pain, 2005. – Vol. 9(4). – p. 463–484. (Total pages: 22, cited: p. 468)

10. International Association for the Study of Pain (IASP). IASP Terminology and Classification of Chronic Pain. – 2020. (Total pages: 15, cited: p.

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Published

2026-04-11