CHILDHOOD VACCINATIONS
Keywords:
Vaccination, Immunization, Children, Infectious diseases, Public health, Herd immunityAbstract
Childhood vaccinations are one of the most effective public health interventions for preventing infectious diseases and reducing child mortality worldwide. This article provides a comprehensive overview of childhood immunization, including its importance, types of vaccines, mechanisms of action, and global impact. Vaccination programs have significantly reduced the incidence of life-threatening diseases such as measles, polio, diphtheria, and pertussis. The study also highlights the role of herd immunity, vaccination schedules, and challenges such as vaccine hesitancy and unequal access. The findings emphasize the importance of maintaining high vaccination coverage to protect both individuals and communities. Strengthening immunization systems and increasing public awareness are essential to ensure global health security and prevent disease outbreaks.
References
1. Bogduk N. On the definitions and physiology of back pain, referred pain, and radicular pain. Pain. (2009) 147:17–9. doi: 10.1016/j.pain.2009.08.020
2. Merskey H, Bogdduk N. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. Pain Suppl. (1986) 3:S1–S226.
3. Vecchiet L, Vecchiet J, Giamberardino MA. Referred muscle pain: clinical and pathophysiologic aspects. Curr Rev Pain. (1999) 3:489–98. doi: 10.1007/ s11916-999-0077-y
4. Affaitati G, Costantini R, Tana C, Cipollone F, Giamberardino MA. Co-occurrence of pain syndromes. J Neural Transm. (2020) 127:625–46. doi: 10.1007/s00702-019-02107-8
5. Graven-Nielsen T. Fundamentals of muscle pain, referred pain, and deep tissue hyperalgesia. Scand J Rheumatol Suppl. (2006) 122:1–43. doi: 10.1080/03009740600865980
6. Whitty C, Willison RGJL. Some aspects of referred pain. Lancet. (1958) 272:226–31. doi: 10.1016/S0140-6736(58)90058-8
7. Vulfsons S, Bar N, Eisenberg E. Back pain with leg pain. Curr Pain Headache Rep. (2017) 21:32. doi: 10.1007/s11916-017-0632-x
8. Giamberardino MA. Referred muscle pain/hyperalgesia and central sensitisation. J Rehabil Med. (2003) 35:85–8. doi: 10.1080/16501960310010205
9. Luz LL, Fernandes EC, Sivado M, Kokai E, Szucs P, Safronov BV. Monosynaptic convergence of somatic and visceral C-fiber afferents on projection and local circuit neurons in lamina I: a substrate for referred pain. Pain. (2015) 156:2042–51. doi: 10.1097/j.pain.0000000000000267
10. Merskey H, Bogduk N. Classification of chronic pain. Descriptions of chronic pain syndromes and definition of pain terms. Seattle: IASP Press (1994) 1–28.
11. Hockaday JM, Whitty CW. Patterns of referred pain in the normal subject. Brain. (1967) 90:481–96. doi: 10.1093/brain/90.3.481
12. McCall IW, Park WM, O’Brien JP. Induced pain referral from posterior lumbar elements in Normal subjects. Spine (Phila Pa 1976). (1979) 4:441–6.
13. Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: from mechanisms to treatment. Physiol Rev. (2021) 101:259–301. doi: 10.1152/physrev.00045.2019
14. Moore CI, Stern CE, Dunbar C, Kostyk SK, Gehi A, Corkin S. Referred phantom sensations and cortical reorganization after spinal cord injury in humans. Proc Natl Acad Sci U S A. (2000) 97:14703–8. doi: 10.1073/pnas.250348997
