CHRONIC PAIN
Abstract
Chronic pain, defined as pain persisting beyond three months, affects approximately 20% of adults globally. Unlike acute pain, which serves as a warning signal, chronic pain is a maladaptive condition involving complex neuroplastic changes in the central and peripheral nervous systems. This article explores the pathophysiology of chronic pain, its distinction from acute pain, the biopsychosocial model of management, pharmacological interventions (NSAIDs, opioids, adjuvants), and non-pharmacological strategies (CBT, physical therapy, mindfulness). The article concludes with an original crossword puzzle to reinforce key terminology
References
1. Cohen, S. P., Vase, L., & Hooten, W. M. (2021). Chronic pain: an update on burden, best practices, and new advances. The Lancet, 397(10289), 2082-2097.
2. Treede, R. D., Rief, W., Barke, A., et al. (2019).
3. [05.04.2026 23:10] Ismoilxon: Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain, 160(1), 19-27.
4. Finnerup, N. B., Attal, N., Haroutounian, S., et al. (2015). Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. The Lancet Neurology, 14(2), 162-173.
5. Dowell, D., Haegerich, T. M., & Chou, R. (2022). CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. MMWR Recommendations and Reports, 71(3), 1-95.
6. Vlaeyen, J. W., & Linton, S. J. (2012). Fear-avoidance model of chronic musculoskeletal pain: 12 years on. Pain, 153(6), 1144-1147.
7. Khera, T., & Rangasamy, V. (2021). Mindfulness and acceptance-based therapy for chronic pain. Current Pain and Headache Reports, 25(5), 1-9.
8. National Institute of Neurological Disorders and Stroke. (2023). Chronic Pain Information Page. Retrieved from [NINDS website - hypothetical].
9. Woolf, C. J. (2010). Central sensitization: implications for the diagnosis and treatment of pain. Pain, 152(3 Suppl), S2-S15.
