THE DIFFERENCE BETWEEN ACUTE AND CHRONIC INFLAMMATION
Keywords:
Acute inflammation, chronic inflammation, neutrophils, macrophages, cytokines, resolution of inflammation, specialized pro-resolving mediators, fibrosis, systemic effects, metaflammationAbstract
Inflammation is the body’s fundamental protective response to harmful stimuli such as pathogens, damaged cells, or irritants. It plays a vital role in eliminating the cause of injury and initiating the healing process. However, inflammation manifests in two distinct forms: acute and chronic. Acute inflammation is a rapid, short-term response that is usually beneficial and self-limiting, whereas chronic inflammation is a prolonged, low-grade process that can lead to tissue destruction, fibrosis, and contributes to the development of many serious diseases. This article provides a comprehensive overview of the differences between acute and chronic inflammation, including their causes, underlying mechanisms, clinical manifestations, diagnostic approaches, and management strategies. Understanding these distinctions is essential for accurate diagnosis, effective treatment, and prevention of long-term complications in clinical practice.
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