BOLA RIVOJLANISHIDA ONA SUTINING AHAMIYATI VA UNING IMMUNOLOGIK XUSUSIYATLARI
Keywords:
ona suti, immunoglobulin A, laktoferrin, neonatal immunitet, mikrobioma, epigenetika, passiv immunizatsiya.Abstract
Mazkur maqolada ona sutining bola rivojlanishidagi o‘rni va uning noyob immunologik xususiyatlari tahlil qilinadi. Ona suti nafaqat oziq moddalar manbai, balki chaqaloqning passiv immunitetini shakllantiruvchi muhim biologik suyuqlikdir. Tarkibidagi immunoglobulin A (sIgA), laktoferrin, oligosaxaridlar, sitokinlar va immun hujayralar orqali infeksiyalarga qarshi himoya mexanizmlarini faollashtiradi. Adabiyotlar tahlili asosida ona suti bilan oziqlantirishning erta neonatal davrda nafas va oshqozon-ichak infeksiyalari, allergik kasalliklar va semirish xavfini kamaytirishi isbotlangan. Yangi tadqiqotlar mikroRNK va epigenetik mexanizmlar orqali sutning uzoq muddatli immunomodulyatsiyasini ochib bermoqda
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