BRONXIAL ASTMANING TURLI FENOTIPLARI VA T2-ENDOTIPIDA MOLEKULYAR ALLERGEN SENZIBILIZATSIYASI
Keywords:
bronxial astma, fenotip, endotip, T2-yallig‘lanish, molekulyar allergologiya, sensibilizatsiya, IgE, eozinofil, FeNO.Abstract
Bronxial astma klinik kechishi, yallig‘lanish mexanizmlari va davolashga javobi bo‘yicha geterogen kasallikdir. Zamonaviy yondashuvda klinik fenotip bilan bir qatorda biologik endotiplarni aniqlash muhim. T2-yallig‘lanish bilan bog‘liq astmada eozinofillar, FeNO, umumiy IgE va allergenga xos IgE muhim biomarkerlar hisoblanadi. Molekulyar allergologiya esa allergenning individual komponentlariga nisbatan IgE-sensibilizatsiyani aniqlash va haqiqiy sensibilizatsiyani kross-reaktivlikdan farqlash imkonini beradi.
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