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THE RELATIONSHIP BETWEEN OBESITY AND DIABETES.

Authors

  • Sulaymonova Sevinch

    Student of Samarkand state medical university Faculty of General medicine, Group - 168
    Author
  • Asatullayev Rustamjon Bakhtiyarovich

    Trainee assistant at Samarkand state medical university
    Author

Keywords:

Obesity, Diabetes Mellitus, Type 2 Diabetes, Insulin Resistance, Metabolic Syndrome, Adiposity, Pathophysiology, Prevention

Abstract

Obesity and type 2 diabetes (T2D) represent significant global health challenges with increasing prevalence worldwide. This article explores the profound relationship between obesity and the development of T2D. Research consistently demonstrates that excess adiposity leads to insulin resistance and metabolic dysfunction, crucial precursors to impaired glucose homeostasis. A comprehensive understanding of this intricate link is vital for developing effective prevention, early diagnosis, and management strategies. We review the pathophysiological mechanisms and clinical implications connecting these two prevalent conditions.

References

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[3] Reaven, Gerald M. The Metabolic Syndrome: A Clinical Guide. Cham: Springer, 2020.

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[6] van der Heijden, Annemarie J. T., et al. "Obesity and type 2 diabetes: the role of adipose tissue dysfunction." Trends in Endocrinology and Metabolism, vol. 33, no. 1, 2022, pp. 50-62.

[7] Loos, Ruth J. F., et al. "Obesity and type 2 diabetes genetics: from mechanisms to precision medicine." Nature Reviews Genetics, vol. 23, no. 10, 2022, pp. 605-621.

[8] Kim, Se Hwa, et al. "Obesity, insulin resistance, and type 2 diabetes: a complex relationship." Endocrinology and Metabolism, vol. 35, no. 1, 2020, pp. 1-12.

[9] Schernhammer, Eva S., et al. “The Global Epidemic of Obesity and Type 2 Diabetes: A Review of Current Evidence and Future Directions.” Current Opinion in Endocrinology, Diabetes, and Obesity, vol. 28, no. 1, 2021, pp. 1-7.

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Published

2026-04-15