“ALTSGEYMER KASALLIGI PATOGENEZIDA ICHAK MIKROBIOTASINING ROLI”
Keywords:
Alzheimer’s disease, gut microbiota, neurodegeneration, amyloid-beta, gut-brain axis, dysbiosis, neuroinflammation, lipopolysaccharides, short-chain fatty acids, microglia.Abstract
This scientific article extensively analyzes the role of gut microbiota in the pathogenesis of Alzheimer’s disease, one of the most pressing issues in modern medicine. Recent studies demonstrate that communication carried out through the “gut-brain axis” significantly influences neurodegenerative processes in the brain, particularly the accumulation of amyloid-beta proteins. The article provides a detailed explanation of mechanisms such as the impact of intestinal dysbiosis on systemic inflammation, the increased permeability of the blood-brain barrier caused by bacterial endotoxins, and the activation of microglial cells. Furthermore, the article discusses promising approaches for the prevention and treatment of Alzheimer’s disease through microbiota modulation.
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