THE IMPACT OF PROBIOTICS ON HUMAN IMMUNE FUNCTION: CURRENT EVIDENCE AND CLINICAL PERSPECTIVES
Keywords:
probiotics, immunity, microbiota, immune regulation, inflammation, cytokines, microbiomeAbstract
The human immune system is influenced by numerous environmental and biological factors, among which the intestinal microbiota plays a central role. Probiotics, defined as live microorganisms that confer health benefits when administered in adequate amounts, have attracted considerable scientific attention because of their potential immunomodulatory effects. This study aimed to evaluate current evidence regarding the impact of probiotics on human immune function and to analyze their clinical significance in disease prevention and management. A comprehensive review and analysis of contemporary scientific literature were conducted using major biomedical databases. The findings demonstrate that probiotics contribute to immune homeostasis by enhancing intestinal barrier integrity, modulating cytokine production, promoting regulatory immune responses, and improving resistance against infectious diseases. Clinical studies indicate beneficial effects in gastrointestinal disorders, allergic diseases, respiratory tract infections, and immune-mediated conditions. These observations suggest that probiotics represent a promising adjunctive strategy for maintaining immune health and preventing disease progression.
References
1. Hill C., Guarner F., Reid G., et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of probiotics. Nature Reviews Gastroenterology & Hepatology. 2014;11(8):506–514.
2. Sanders M.E., Merenstein D.J., Reid G., Gibson G.R., Rastall R.A. Probiotics and prebiotics in intestinal health and disease. Gut. 2019;68(6):1136–1150.
3. Belkaid Y., Hand T.W. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121–141.
4. Plaza-Díaz J., Ruiz-Ojeda F.J., Gil-Campos M., Gil A. Mechanisms of action of probiotics. Advances in Nutrition. 2019;10(Suppl_1):S49–S66.
5. Markowiak P., Śliżewska K. Effects of probiotics on human health. Nutrients. 2017;9(9):1021.
6. Shi L.H., Balakrishnan K., Thiagarajah K., Mohd Ismail N.I., Yin O.S. Beneficial properties of probiotics. Tropical Life Sciences Research. 2016;27(2):73–90.
7. Bron P.A., Kleerebezem M., Brummer R.J., et al. Can probiotics modulate human disease by impacting intestinal barrier function? British Journal of Nutrition. 2017;117(1):93–107.
8. Derrien M., van Hylckama Vlieg J.E.T. Fate, activity, and impact of ingested bacteria within the human gut microbiota. Trends in Microbiology. 2015;23(6):354–366.
